OBJECTIVE： To provide references for the cultivation of international entrepreneurial talents in TCM colleges. METHODS： Through literature investigation and data mining analysis， the opportunity and present situation of talent cultivation in TCM colleges were analyzed under the background of “One Belt and One Road”. The corresponding research ideas and countermeasures were put forward. RESULTS & CONCLUSIONS： The implementation of “One Belt and One Road” needs large amount of the international TCM talents， and has provided new opportunities for the development of TCM colleges. At present， the construction of TCM discipline and cultivation of international entrepreneurial talents cannot meet the needs of the internationalization of TCM， and the shortage of internationalized entrepreneurial talents has become a shackle for TCM becoming international. The education department， TCM industry and TCM colleges can change the educational concept based on TCM industry， national conditions and the talents. The education system can be improved through the integration and innovation of curriculum system， and the formation of a more open and inclusive teaching model. Global cooperation mechanism can be established through developing international entrepreneurial talents cultivation platform， enlarging production-study-research-cooperative international communication mode and cooperation scale. At the same time， the organizations do top-level design， form complementary advantages， and promote the practice of international entrepreneurial talents cultivation so as to establish “integration， innovation， coordination and opening” of internationalization TCM entrepreneurial talents cultivation mode， and provide international TCM entrepreneurial talents in China.