OBJECTIVE： To investigate the effects of valsartan on related indexes of elderly patients with hypertension with paroxysmal atrial fibrillation. METHODS： A total of 128 patients with hypertension with paroxysmal atrial fibrillation were randomly divided into observation group and control group， with 64 cases in each group. Control group was given Amlodipine tablets 5-10 mg/d， once a day+Hydrochlorothiazide tablets 12.5 mg/d，once a day，orally in the morning. Observation group was additionally given Valsartan capsule 80-160 mg/d orally， once a day， in the morning. Both groups were treated for 12 weeks. The levels of Hs-CRP， IL-6 and blood pressure， LVEF， LAD， maximum P wave duration （Pmax）， P wave dispersion （Pd） before and after treatment， the occurrence of ADR were observed and compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in above indexes （P＞0.05）. After treatment， Hs-CRP，IL-6 levels and LAD of 2 groups were significantly lower than before， and Hs-CRP， IL-6 levels in the observation group was significantly lower than the control group while LAD was higher than the control groups； LVEF was significantly higher than before， but the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. After treatment， SBP and DBP of 2 groups were significantly lower than before （P＜0.05）， but there was no statistical significance between 2 groups （P＞0.05）. Pmax and Pd in the observation group were significantly lower than before，and lower than the control group at the same time（P＜0.05）， while there were no significantly of Pmax and Pd in the control group before and after treatment（P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： For elderly patients with hypertension with paroxysmal atrial fibrillation， valsartan shows good hypotensive effect and effectively improves serum inflammatory factor levels and cardiac function related indexes.