OBJECTIVE： To investigate the effects of different diuretic regimens on related indicatora in hepatocellular carcinoma patients after hepatic resection. METHODS： A total of 60 hepatocellular carcinoma patients undergoing hepatic resection were randomly divided into study group （30 cases） and control group （30 cases）. After surgery， study group was given Spironolactone tablet 100 mg+Furosemide tablet 40 mg， qd， after breakfast； Control group was given Spironolactone tablet 100 mg orally， bid， after breakfast and at 16：00+Furosemide tablet 20 mg， qd， after breakfast. Electrolyte， liver and renal function of 2 groups were rechecked every 3 days； diuretic regimen was adjusted according to body weight and volume of liquid intake and output. The effectiveness indexes of diuretic treatment were observed in 2 groups，such as the decrease of body weight， case number of effective diuretic treatment，frequency of intravenous dieresis，frequency of hydroxyethl starch use，frequency of night arination，postoperative hospitalization stay，the time of ascites extinction； serum sodium，serum potassium， serum creatinine， blood urea nitrogen， serum albumin， ALT，AST，GGT， the occurrence of ADR were observed before and after treatment. RESULTS： The nocturnal micturition frequency of study group was significantly lower than that of control group， with statistical significance （P＜0.05）. There was no significant difference in the decrease of body weight， response rate of diuretic treatment， frequency of intravenous dieresis， frequency of hydroxyethyl starch use， postoperative hospitalization stay or the time of ascites extinction between 2 groups （P＞0.05）. After treatment， the levels of serum sodium and serum albumin in 2 groups were decreased significantly， compared to before treatment； the levels of blood urea nitrogen， serum potassium and ALT， AST，GGT in 2 groups were significantly higher than before treatment， with statistical significance （P＜0.05）. There was no statistical significance in the levels of serum sodium， serum potassium， blood urea nitrogen， serum albumin or ALT， AST， GGT between 2 groups （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Both two diuretic regimens can effectively avoid the occurrence of postoperative ascites formation and related complication in patients hepatocellular carcinoma after hepatic resection. The drug regimens of spironolactore 100 mg，qd+furosemide 40 mg，qd after breakfast can significantly reduce nocturnal micturition frequency and improve medication compliance.