OBJECTIVE： To observe clinical efficacy and safety of safflower yellow pigment in the treatment of elderly patients with diabetic nephropathy complicated with acute myocardial infarction. METHODS： A total of 102 elderly patients with diabetic nephropathy complicated with acute myocardial infarction were selected from our hospital during Jan. 2013-Jun. 2015， and then divided into observation group （52 cases） and control group （50 cases） according to random number table. Control group was given routine treatment as anticoagulation， regulating blood lipid， controlling blood glucose and blood pressure. Observation group was additionally given Safflower yellow pigment for injection 150 mg added into 0.9％ Sodium chloride injection 250 mL， ivgtt，qd， on the basis of control group. Both groups received treatment for 2 weeks. Clinical efficacies of 2 groups were observed. Renal function indexes （UMA， Scr， BUN， TC， TG）， cardiac function indexes （EF， SV， CO， CI）， inflammatory factors （CRP， IL-6， TNF-α） and hemorheological indexes （whole blood high-shear viscosity， whole blood low-shear viscosity， hematocrit， fibrinogen and platelet aggregation rate） were compared between 2 groups before and after treatment. The occurrence of ADR was recorded in 2 groups. RESULTS： Total response rate of observation group was 96.15％， which was significantly higher than 88.00％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in renal function indexes， cardiac function indexes， inflammatory factors or hemorheological indexes between 2 groups （P＞0.05）. After treatment， renal function indexes， inflammatory factors and hemorheological indexes of 2 groups were decreased significantly， while cardiac function indexes were increased significantly； above indicators of the observation group was significantly better than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Safflower yellow pigment shows significant therapeutic efficacy for elderly patients with diabetic nephropathy complicated with acute myocardial infarction， can significantly improve renal function and cardiac function， decrease inflammatory factor levels and improve hemorheological indexes with good safety.