OBJECTIVE： To optimize the purification technology of total saponins from Asparagus cochinchinensis with macroreticular resin. METHODS： Using content of total saponins from A. cochinchinensis as index， single factor test was used to investigate the macroreticular resin model， sampling adsorption time， mass concentration of the column， adsorption capacity， volume fraction and the amount of elution solvent， elution rate， and optimize the purification technology. And verification test was conducted. RESULTS： HPD-300 macroreticular resin showed strong absorption and desorption property. The optimal purification technology was that sampling adsorption time was 60 min， mass concentration of sample liquid was 0.1 g/mL， adsorption capacity was 120 mL （15 BV）， it was eluded with 60％ ethanol solution with 3 BV and elution rate was 4 BV/h. In the verification test， the average desorption rate of total saponins was 68.30％ （RSD＝0.95％， n＝3）. CONCLUSIONS： Optimized purification technology is stable， feasible， and can easily separate and purify the total saponins from A. cochinchinensis.