OBJECTIVE： To investigate the effects of Compound Leonurus artemisia ointment combined with Drospirenone and ethinylestradiol tablets on serum progesterone and T helper （Th） 1/Th2 cytokine after medical abortion. METHODS： A total of 228 patients underwent medical abortion selected from obstetrical outpatient of our hospital during our hospital during Mar. 2013 to Jul. 2015 as research object were divided into control group （109 cases） and observation group （119 cases） according to random number table. Control group was given Cefuroxime axetil tablets 0.25 g， po， bid， for consecutive 6 d for anti-infective treatment+ Drospirenone and ethinylestradiol tablets one tablet， po， qd， 21 d as a treatment course， 8 d later receiving second course， 3 courses in total after fetal sac exclusion. Observation group was additionally given Compound L. artemisia ointment 10 g， po， bid，7 d as a treatment course， 2 courses in total on the basis of control group. The levels of serum progesterone and Th1（TNF-α， IFN-γ， IL-2）/Th2 cytokine （IL-4， IL-6， IL-10） were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in serum progesterone or Th1/Th2 cytokine levels between 2 groups （P＞0.05）. After treatment， serum progesterone， TNF-α， IL-2 and IL-6 levels of 2 groups were decreased significantly， and above indexes of observation group were significantly lower than those of control group. The levels of IL-4 and IL-10 in 2 groups were increased significantly， and above indexes of observation group were significantly higher than control group， with statistical significance （P＜0.05）. After treatment， IFN-γ levels of 2 groups were decreased significantly， but there was no statistical significance between 2 groups （P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Compound L. artemisia ointment combined with Drospirenone and ethinylestradiol tablets can regulate immune function of patients after medical abortion， and promote dynamic balance of Th1/Th2 cytokines with good safety.