OBJECTIVE： To establish the method for the content determination of 4 active components in Compound xiaosuanzao chewable tablets. METHODS： HPLC-ELSD method was adopted. The determination was performed on a Grace Brava C18-BDS column with mobile phase consisted of acetonitrile-water （gradient elution） at the flow rate of 1.0 mL/min. The column temperature was 25 ℃， and sample size was 20 μL. The drift tube temperature is 100 ℃， and the carrier gas flow rate is 2.9 L/min. RESULTS： The linear ranges of betulic acid， betulinol， pachymic acid and glycyrrhizic acid were 44.50-890.0 μg/mL（r＝0.999 3）， 20.28-405.6 μg/mL （r＝0.999 7）， 20.50-656.0 μg/mL（r＝0.999 7） and 10.50-336.0 μg/mL（r＝0.999 6）， respectively. RSDs of precision， stability and reproducibility were all lower than 3.0％. The recoveries were 99.44％-101.12％（RSD＝0.57％，n＝6）， 99.41％-100.39％（RSD＝0.34％，n＝6）， 99.31％-100.46％（RSD＝0.51％，n＝6）， 98.96％-101.19％（RSD＝0.84％，n＝6）， respectively. CONCLUSIONS： The method is simple， precise， stable and reproducible， and can be used for simultaneous determination of 4 active components in Compound xiaosuanzao chewable tablets.