OBJECTIVE： To establish a method for simultaneous determination of sodium danshensu， protocatechuic aldehyde， salvianolic acid B and phellodendrine hydrochloride in Shenbai shuxin granules. METHODS： HPLC method was adopted. The separation was performed on Waters sunfire-C18 column with mobile phase consisted of acetonitrile-0.05％ trifluoroacetic acid （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelength was set at 288 nm， and the column temperature was 30 ℃. The sample size was 5 μL. RESULTS： The linear ranges of sodium danshensu， protocatechuic aldehyde， salvianolic acid B and phellodendrine hydrochloride were 0.040 01-1.600 46 μg（r＝0.999 9），0.013 84-0.553 7 μg（r＝0.999 9），0.049 32-1.972 94 μg（r＝0.999 6）， 0.014 46-0.578 6 μg（r＝0.999 8）. The limits of quantitation were 7.68， 2.66， 4.74， 1.38 ng， and the limits of detection were 1.92，0.66， 2.36， 0.69 ng， respectively. RSDs of precision， stability and reproducibility tests were all lower than 2％. The recoveries were 98.846％-100.762％（RSD＝0.77％，n＝6）， 96.632％-99.463％（RSD＝0.98％，n＝6）， 98.541％-100.432％（RSD＝0.82％，n＝6）， 98.607％-101.521％（RSD＝1.11％，n＝6）， respectively. CONCLUSIONS： The method is simple， accurate and precise. It can be used for 4 components in Shenbai shuxin granules.