OBJECTIVE： To prepare the lurasidone hydrochloride solid dispersion， and improve its dissolution rate. METHODS： Taking povidone K30 as the carrier， solvent method was used to prepare the lurasidone hydrochloride solid dispersion with different drug-load ratios （1 ∶ 0.5， 1 ∶ 1， 1 ∶ 2）. The in vitro dissolution rates of 3 kinds of lurasidone hydrochloride solid dispersion with physical mixture （lurasidone hydrochloride-povidone K30） and original preparation were compared. X-ray powder diffraction method was adopted to analyze the crystal structures of raw material of lurasidone hydrochloride， povidone K30 and accessories， physical mixture （1 ∶ 2） and accessories， and lurasidone hydrochloride solid dispersion （1 ∶ 2） and accessories. RESULTS： Compared with physical mixture， the dissolution rate of lurasidone hydrochloride solid dispersion with drug-load ratios of 1 ∶ 0.5， 1 ∶ 1，   1 ∶ 2 was significantly improved， and the dissolution rate of solid dispersion was increased as the increase of the carrier ratio. The in vitro dissolution rates of lurasidone hydrochloride solid dispersion with drug-load ratio of 1 ∶ 2 and original preparation were respectively 101.2％ and 100.2％ in 20 min. X-ray powder diffraction showed， there were characteristic absorption peaks of lurasidone hydrochloride and accessories in physical mixture； the characteristic absorption peak of lurasidone hydrochloride in solid dispersion disappeared basically， and the characteristic absorption peak of accessories still existed. CONCLUSIONS： The in vitro dissolution of lurasidone hydrochloride solid dispersion with drug-load ratio of 1 ∶ 2 is similar to original preparation， and lurasidone hydrochloride exists in the solid dispersion as amorphous form.