OBJECTIVE： To investigate the clinical efficacy and bacteriological efficacy of biapenem in the treatment of acute bacterial infection， and its effects on serum IL-6 and hs-CRP levels. METHODS： A total of 241 patients with acute bacterial infection of respiratory system and urinary tract system selected from our hospital during Apr. 2015-Apr. 2016 were divided into control group （119 cases） and observation group （122 cases） according to random number table. Control group was given Meropenem for injection 0.5 g added into 100 mL  0.9％ NaCl injection intravenously， tid. Observation group was given Biapenem for injection 0.3 g added into 100 mL 0.9％ NaCl injection intravenously， bid. Treatment course of 2 groups lasted for 7-14 d. Clinical efficacies， bacteriological efficacies， serum interleukin-6 （IL-6） and hypersensitive C-reactive protein （hs-CRP） levels， the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate， bacterial culture positive rate， bacterial clearance rate and the incidence of ADR were 88.24％， 56.30％， 87.14％， 13.45％ in control group and 93.44％， 55.74％， 93.06％， 10.66％ in observation group， without statistical significance （P＞0.05）. Before treatment， there was no statistical significance in serum IL-6 or hs-CRP levels between 2 groups （P＞0.05）. Compared with before treatment， serum IL-6 and hs-CRP levels of 2 groups were decreased significantly after treatment， with statistical significance （P＜0.05）； there was no statistical significance between 2 groups （P＞0.05）. CONCLUSIONS： Biapenem in the treatment of acute bacterial infection of respiratory system and urinary tract system has excellent efficacy， and can significantly reduce inflammatory factor level with good safety. Response rate and safety of biapenem are similar to those of meropenem， so drugs should be selected according to specific condition of patients.