OBJECTIVE： To establish an effective technical system to achieve the informatization management in drug production process， and provide reference for the drug informatization management during production process in China. METHODS： Through analyzing the common problems existing in informatization management in drug production process， above problems were solved by interactive integration marketing system （IIMS） based on mobile internet. Informatization supervision was conducted for the production progress of a batch of drugs in a pharmaceutical production enterprise， and feasibility of the technical system was investigated. RESULTS： There were problems commonly existed in the production process， such as supervision and data collection out of touch， no advanced means， delayed and closed informatization transmission， high cost of informatization collection， hard to develop， etc. IIMS consisted of transit label， informatization collection terminal and monitoring management platform had achieved batch production records paperless data interaction and solved informatization interaction and supervision issues in process of drug quality. In the actual study， IIMS totally supervised 15 links from raw materials purchasing to finished products， and all data were successfully collected. IIMS achieved the real-time remote control of data to make the government easy to regulate， without changing the operational processes， and did not cause economic burden to the enterprises. CONCLUSIONS： The technical system is suitable for the informatization management in drug production process in pharmaceutical production enterprise， and it can be extended to the scientific research institutes and drug supervision departments in the further.