OBJECTIVE： To provide reference for local colleges to cultivate innovative ability of applied talents for pharmacy major. METHODS： With innovative thinking， innovative methods and innovative practice ability training as the starting points， the cultivation of students’ innovative ability permeated all aspects of the teaching process mainly through optimizing the curriculum system， deepening the teaching reform， strengthening the project-driven and expanding the practice platform construction. RESULTS： The TMP trinity pharmacy professional applied talents innovation ability training system was constructed through adjusting curriculum system and credit ratio， strengthening the setting of humanities course， establishing professional core， professional refinement and professional extension courses， increasing the proportion of elective course， deepening the teaching reform from four aspects of teaching， learning， evaluation and construction； encouraging students to compete； establishing “three phase-four module” multidimensional practice teaching platform. CONCLUSIONS： Established system has realized the stereoscopic creation of students’ innovative thinking， diversified methods of innovation and multi-levels of innovation and practice. Students have got a coordinated development in the quality， knowledge， ability. It is helpful to improve the quality of talents cultivation in local colleges.