OBJECTIVE： To establish a method for simultaneous determination of 5 kinds residual ethanol， acetone， ethylacetate， N，N-diisopropylethylamine and toluene in favipiravir. METHODS： Headspace GC was adopted. The determination was performed on DB-624 capillary column， temperature programmed. The inlet temperature was 220 ℃， and detector was flame ionization detector with temperature of 250 ℃. Nitrogen was used as carrier gas at flow rate of 2.0 mL/min， split ratio was 10 ∶ 1， headspace equilibrium temperature was 80 ℃， equilibrium time was 20 min and headspace sample size was 1 mL. RESULTS： The linear range was 10.0-501.4 μg/mL for ethanol（r＝0.999 9），10.0-501.4 μg/mL for acetone（r＝0.999 9），10.1-502.6 μg/mL for ethylacetate（r＝0.999 9），0.2-11.4 μg/mL for N，N-diisopropylethylamine（r＝0.999 9）and 1.8-89.4 μg/mL for acetone（r＝0.999 7）. The limits of quantification were 5.3， 3.4， 5.2， 6.1 and 20.4 μg/mL， and the limits of detection were 1.4， 1.1， 1.3， 1.6， 5.9 μg/mL. RSD of precision test was lower than 4.0％， and RSDs of acetone in stability and reproducibility tests were both lower than 4.0％. The recoveries were 96.61％-99.70％（RSD＝1.01％，n＝9）， 95.81％-99.50％（RSD＝1.29％，n＝9）， 96.42％-99.76％（RSD＝1.24％，n＝9）， 96.36％-99.30％（RSD＝1.19％，n＝9）， 97.00％-99.51％（RSD＝0.82％，n＝9）. CONCLUSIONS： The method is simple， accurate， reproducible and can be used for simultaneous determination of 5 organic solvents in favipiravir.