OBJECTIVE： To investigate the role of clinical pharmacists in pediatric severe infection treatment， and to provide reference for rational drug use in clinic. METHODS： Based on related typical cases， the breakthrough points of clinical pharmacists providing pharmaceutical care in pediatric severe infection treatment plan were introduced. RESULTS： Clinical pharmacists formulated multi-drug resistance pathogenic antibacterial plan according to the results of pathogenic microbiological examination， use pharmacokinetics/pharmacodynamics， excluded interference to pediatric anti-infection treatment from ADR， and guideline and economical factors of patients. CONCLUSIONS： Clinical pharmacists adopt professional knowledge of pharmacy to provide pharmaceutical care in pediatric severe infection treatment and play professional assisted role so as to guarantee safe， effective and economical treatment.