OBJECTIVE： To develop a method for simultaneous determination of harpagide， harpagoside， chlorogenic acid， caffeic acid and phillyrin in Xiaoer qingyan granules. METHODS： HPLC method was adopted. The determination was performed on Zorbax SB-C18 column with mobile phase consisted of acetonitrile-0.1％ phosphoric acid solution （gradient elution） at a flow rate of 1.0 mL/min. The detection wavelength was set at 210 nm （0-13 min， harpagide）， 327 nm （13-25 min， chlorogenic acid and caffeic acid）， 277 nm （25-29 min， phillyrin）， 210 nm （29-40 min， harpagosid）； the column temperature was 30℃， and sample size was 10 μL. RESULTS： The linear ranges of harpagide， harpagosid， chlorogenic acid， caffeic acid and phillyrin were 8.400-168.0 ng（r＝0.999 6），11.30-226.0 ng （r＝0.999 8）， 128.8-257.6 ng （r＝0.999 3）， 8.110-162.2 ng（r＝0.999 6），29.69-593.8 ng（r＝0.999 4）， respectively. LOQs of the 5 components were 33.39， 451.2， 515.2， 324.5， 1 188  ng/mL； LODs were 8.348， 112.8， 128.8， 81.12， 297.0 ng/mL， respectively； RSDs of precision， stability and reproducibility tests were all lower than 2.0％. The recoveries were 96.39％-98.64％（RSD＝0.83％，n＝6）， 96.60％-98.89％（RSD＝0.89％，n＝6）， 96.28％-99.22％（RSD＝1.25％，n＝6）， 96.49％-99.54％（RSD＝1.16％，n＝6）， 96.26％-99.70％（RSD＝1.30％，n＝6）， respectively. CONCLUSIONS： The method is simple， accurate and suitable for simultaneous determination of 5 components in Xiaoer qingyan granules