OBJECTIVE： To compare the differences in the volatile ingredients of raw products and wine processed products of Ligusticum chuanxiong， and provide reference for its pharmacological activity research and clinical application. METHODS： Headspace solid phase microextraction-GC/MS was used to analyze the volatile components of L. chuanxiong before and after processed with wine. And area normalization method was adopted to calculate the relative percentage content of each component. RESULTS： 28 components were isolated from the raw products and 24 components were identified， accounting for 99.70％ of total volatile components. 2-methyl-2，3-dihydro-1H-inden-2-ol （20.06％）， α-selinene （17.97％） and 4-ethyl-3-nonen-5-yne （9.24％） were higher in contents. 21 components were isolated from the wine processed products and 18 components were identified， accounting for 89.74％ of total volatile components. 4-ethyl-nonen-5-yne （12.97％） was the highest in content， followed by 4-carene （11.74％） and α-selinene （10.79％）. Compared with raw products， the contents of active components α-pinene and β-elemene were increased. CONCLUSIONS： The volatile components and their relative contents of L. chuanxiong before and after processed with wine show certain differences， and volatile components after wine processed are relatively reduced. However， contents of the components with analgesic effect are increased， and its analgesic effect is superior to raw products.