OBJECTIVE： To optimize the extraction technology of total polyphenol and total flavonoid in Gardenia jasminoides. METHODS： Plackett-burman （PB） design was used to select the ethanol volume fraction， liquid-solid ratio， particle size， extraction time and extraction temperature to determine the key factor affecting the extraction of total polyphenol and total flavonoids in G. jasminoides. Then central composite design （CCD） was combined with response surface method to optimize the extraction technology， and verification test was conducted. RESULTS： The optimal extraction conditions of total polyphenol were 40％ ethanol， particle size of 0.20 mm， extraction temperature of 60 ℃， liquid-solid ratio of 20， and extraction time of 20 min； the optimal extraction conditions of total flavonoids were 40％ ethanol， particle size of 0.20 mm， extraction temperature of 30 ℃， liquid-solid ratio of 20， and extraction time of 20 min. In verification test， the contents of total polyphenol and total flavonoids in G. jasminoides were 1.70％ （RSD＝1.43％， n＝3）， 3.23％ （RSD＝3.72％， n＝3）， with relative error of 1.80％， 8.75％ with predicted values， respectively. CONCLUSIONS： The response surface method based on PB and CCD is simple， reasonable and feasible to optimize the extraction technology of total polyphenol and total flavonoids in G. jasminoides. The method can provide reference for its industrial extraction.