OBJECTIVE: To study related factors of ACEI/ARB drugs in hypertension patients with coronary heart disease. METHODS: Six hundred hypertension patients with coronary heart disease were selected from a hospital during Jan. 2012-Jan. 2015, 310 patients receiving ACEI/ARB drugs were included in observation group, and 290 patients not receiving these drugs were included in control group. General information and lab indexes of 2 groups were collected and analyzed. RESULTS: There were statistical significances in ambulatory arterial stiffness indexes [(0.57±0.13),(0.40±0.11)], 24 h average systolic blood pressure [(146.42±11.24)mmHg, (132.31±9.85)mmHg], 24 h average diastolic blood pressure [(78.14±9.21)mmHg, (82.79±8.33)mmHg], 24 h ambulatory pulse pressure [(64.89±13.57)mmHg,(53.54±9.78)mmHg], drinking rate (58.71%, 28.28%), moderate intensity rate (31.29%, 65.17%), BMI[(33.28±2.07)kg/m2,(23.17±2.86)kg/m2], LVEF [(35.65±11.42)%, (48.01±12.45)%], dyslipidemia rate (66.77%, 30.34%), myocardial infarction rate (68.39%, 39.66%), revascularization rate (69.68%, 33.10%) and duration of coronary heart disease between 2 groups (P<0.05). The duration of coronary heart disease, dyslipidemia, myocardial infarction, revascularization were included in multivariate Logistic regression analysis, with statistical significance (P<0.05). CONCLUSIONS: The application of ACEI/ARB drugs in hypertension patients complicated with coronary heart disease is influenced by many factors; dyslipidemia, myocardial infarction and revascularization are positive independent influential factors of ACEI/ARB drug use in the treatment, but drug use rate will decline with the duration increase.