OBJECTIVE： To optimize the technology conditions of water-soluble chitosan on Huang’e gel water extract solution. METHODS： Using the comprehensive scores of transmittance ratio， impurity removal rate， naringin retention rate as indexes， Box-Behnken response surface method was used to optimize the amount of water-soluble chitosan， shocking time and temperature in clarifying technology， and verification test was conducted. RESULTS： The clarification effect was the best when the volume ratio of TCM extract solution with proportion ≥1.3 to amount of 0.01 g/mL water-soluble chitosan was 2.2， shocking for 100 min at 70 ℃. In the verification test， the average transmittance ratio was 87.3％， impurity removal rate was 41.5％， and naringin retention rate was 131.38％. The measured values of comprehensive scores were 97.35％， 98.92％ and 98.04％， showing relative error of －0.87％， 0.73％ and －0.16％ with the predicted values （98.27％）， respectively. CONCLUSIONS： The method can effectively optimize the clarification technology parameters of water-soluble chitosan on Huang’e gel water extract solution.