OBJECTIVE： To explore the role of clinical pharmacists in the therapy for patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicated with allergic bronchopulmonary aspergillosis （ABPA）. METHODS： Clinical pharmacists participated in the therapy for a AECOPD patient with ABPA. According to patient’s condition， clinical pharmacists suggested adjusting the inhalation order of salbutamol and budesonide aerosol inhalation； stopping cefatriaxone and adjusting to intravenous injection of voriconazole； and then adjusting voriconazole to oral dosage form timely， monitoring therapy duration. Clinical pharmacists paid close attention to therapeutic efficacy and ADR， and provided medication education for patients. RESULTS： Physicians adopted the suggestion of clinical pharmacists to adjust inhalation order of aerosols， the dosage and route of administration of voriconazole. The patient’s condition was improved obviously， and the drug therapy was continued after discharge. CONCLUSIONS： Clinical pharmacists participating in the whole process of treatment improves therapeutic efficacy， reduces the occurrence of ADR and promotes rational drug use in clinic.