OBJECTIVE： To investigate the effects of Cangfu daotan decoction combined with Clomiphene citrate capsule on sex hormone level and endometrial receptivity in patients with polycystic ovary syndrome （PCOS） combined infertility. METHODS： A total of 116 PCOS patients with infertility in the First Affiliated Hospital of Guiyang College of TCM from Jan. 2014 to Dec. 2014 were divided into observation group and control group according to random number table， with 58 cases in each group. Both groups received hormone regulation therapy since the fifth day of menstruation. Control group was given Clomiphene citrate capsule 50 mg， qd； observation group was additionally given one dose of Cangfu daotan decoction， 400 mL after decocted with water， bid， on the basis of control group. Both groups were treated for 3 cycles of menstruation. The levels of serum sex hormone （E2， LH）， endometrial thickness （Em）， endometrial spiral arterial pulsatility index （PI） and resistance index （RI） were compared between 2 groups before and after treatment. The ovulation rate and pregnancy rate were compared between 2 groups after 1-year follow-up. RESULTS： Before treatment， there was no statistical significance in E2， LH， Em， PI or RI between 2 groups （P＞0.05）. After treatment， the levels of E2 and LH as well as Em in 2 groups were increased significantly， while PI and RI were decreased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.06）. After 1-year follow-up， there was no statistical significance in ovulation rate between 2 groups （P＞0.05）. The pregnancy rate of observation group was 41.38％， which was significantly higher than that of control group （22.41％）， with statistical significance （P＜0.05）.  CONCLUSIONS： Cangfu daotan decoction combined with Clomiphene citrate capsule can effectively regulate serum sex hormone levels of PCOS patients with infertility， and improve endometrial receptivity so as to increase pregnancy rate.