OBJECTIVE： To investigate the effects of Tanshinone ⅡA sodium sulfonate injection on levels of P-selectin， glial fibrillary acidic protein （GFAP）， vascular endothelial growth factor （VEGF） and neurological function in patients with acute cerebral infarction. METHODS： A total of 114 patients with acute cerebral infarction selected from Lianyungang First People’s Hospital during Apr. 2013-Apr. 2016 were divided into control group and observation group according to random number table， with 57 cases in each group. Control group was given routine treatment. Observation group was additionally given Tanshinone ⅡA sodium sulfonate injection 40 mg 0.9％ sodium chlonride injection 250 mL， ivgtt， qd. A treatment course lasted for 7 d， and both received 2 courses of treatment. NIHSS scores， the levels of serum P-selectin， GFAP and VEGF were compared between 2 groups before treatment and after 7， 14 d of treatment. The occurrence of ADR was also compared. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. Compared to before treatment， NIHSS score， the levels of serum P-selectin and GFAP in 2 groups were decreased significantly after 7， 14 d of treatment， while the serum level of VEGF was increased significantly. These indexes of 2 groups after 14 d of treatment were significantly better than 7 d of treatment， except for NIHSS score. Above indexes of observation group was significantly better than those of control group during corresponding period， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： For acute cerebral infarction， Tanshinone ⅡA sodium sulfonate injection can significantly reduce the levels of serum P-selectin and GFAP， improve VEGF level and promote the recovery of neurological damage with good safety.