OBJECTIVE： To provide reference for the selection of new edition of Essential Medicine List by quantitative comprehensive evaluation for additional essential medicine. METHODS： The evaluation factors were established according to Delphi method， and Analytic Hierarchy Process （AHP） was conducted to compare the factors in pairs， construct the judgment matrix， calculate the weight coefficients of every factor and do the consistency test. RESULTS： The evaluation model was composed of 6 first-class indexes （including effectiveness， safety， stability， availability， affordability and adaptability） and 24 second-class indexes， and the weight of each index to the target layer was calculated. Among them， the weight of validity and security is the top two. CONCLUSIONS：The weight coefficient can be determined scientifically and reasonably by AHP， and the reliability and operability of the evaluation index system can be improved. It is a useful attempt to explore the selection system of additional essential medicine.