OBJECTIVE： To investigate the effect of Saccharomyces boulardii adjuvant with aluminium phosphate on symptoms and signs disappearance time， immune function and inflammatory factors in children with acute diarrhea. METHODS： Totally 110 children with acute diarrhea were chosen from our hospital during Mar. 2013-Mar. 2016， and then randomly divided into control group and observation group according to random number table， with 55 cases in each group. Control group was given Aluminium phosphate gel 2.5 g， po， qd， on the basis of conventional treatment. Observation group was additionally given S. boulardii capsules 0.25 g， po， bid， on the basis of control group. Both groups were treated for 3 d. Clinical efficacies， symptoms and signs （diarrhea， abdominal pain， vomiting， abnormal stool routine） disappearance time as well as stool frequency， stool character scores， immune function indexes （CD3+， CD4+， CD8+， CD4+/CD8+）， inflammatory factors （IL-6， IL-10， TNF-α） before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （90.91％） was significantly higher than that of control group （70.91％）； the symptoms and signs disappearance time was significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in stool frequency， stool character scores， immune function indexes or inflammatory factor levels between 2 groups （P＞0.05）. After treatment， stool frequency， stool character scores and inflammatory factor levels of 2 groups were significantly lower than before， and the observation group was significantly lower than the control group； the levels of CD3+， CD4+， CD4+/CD8+ were significantly higher than before treatment and control group， and the level of CD8+ was significantly lower than before treatment and control group， with statistical significance （P＜0.05）. There was no significant difference in immune function indexes of control group before and after treatment（P＞0.05）. Total incidence of dry mouth and constipation was 5.45％ in control group and 9.09％ in observation group， without statistical significance （P＞0.05）. CONCLUSIONS： S. boulardii adjuvant with aluminium phosphate in the treatment of pediatric acute diarrhea can efficiently improve symptoms and signs， shorten disease duration， improve immune function and reduce inflammatory reaction with good safety.