OBJECTIVE： To compare the effects of morphine and nalbuphine on related indexes of maternal after cesarean section. METHODS： A total of 120 maternal underwent cesarean section were randomly divided into observation group （60 cases） and control group （60 cases）. After surgery， observation group was given Nalbuphine hydrochloride injection 20 mg+0.75％ Ropivacaine hydrochloride injection 20 mL for patient-controlled epidural analgesia. Control group was given Morphine hydrochloride injection 8 mg+0.75％ Ropivacaine hydrochloride injection 20 mL for patient-controlled epidural analgesia. VAS score， systolic pressure， diastolic pressure， respiration rate （RR）， SpO2 at the onset of analgesia （T0）， 6 h （T1）， 12 h （T2）， 24 h （T3） and 48 h （T4） after analgesia as well as the levels of IL-6， IL-8， CRP and PRL at T0， T3， T4 were observed in 2 groups. The satisfaction rate of analgesia and the occurrence of ADR were also observed. RESULTS： There was no statistical significance in satisfaction rate of analgesia between 2 groups （96.67％ vs. 98.33％，P＞0.05）. At T0， T1， T4， there was no statistical significance in VAS score between 2 groups （P＞0.05）. VAS scores of 2 groups at T2-3 were significantly higher than at T0， T1， T4， with statistical significance （P＜0.05）； but there was no statistical significance between 2 groups （P＞0.05）. There was no statistical significance in diastolic pressure， RR and SpO2 between 2 groups at T0-2（P＞0.05）. The systolic pressure of 2 groups at T3-4 were significantly higher than at T0， with statistical significance （P＜0.05）； but there was no statistical significance between 2 groups （P＞0.05）. There was no statistical significance in the levels of IL-6， IL-8， CRP or PRL between 2 groups at T0（P＞0.05）. The levels of IL-6， IL-8 and CRP in 2 groups at T3 were significantly higher than at T0， but the observation group was significantly lower than the control group； at T4， the levels of IL-6， IL-8 and CRP in control group were significantly higher than at T0， with statistical significance （P＜0.05），but there was no statistical significance in observation group， compared to at T0 （P＞0.05）. The levels of PRL in 2 groups at T3-4 were significantly higher than at T0， and increased gradually as time； the observation group and significantly higher than the control group， with statistical significance （P＜0.05）. The incidence of ADR in observation group was significantly lower than control group， with statistical significance （P＜0.05）. CONCLUSIONS： For maternal after cesarean section，nalbuphine is similar to morphine in analgesic effect and cardiovascular effect， but it is better than morphine in reducing inflammatory level， promoting lactation and safety.