OBJECTIVE： To explore the role of clinical pharmacists participating in the individualized treatment for purulent meningitis. METHODS： Clinical pharmacists participated in the therapy for a patient with purulent meningitis complicated with Staphylococcus aureus infection. According to patient’s condition， clinical pharmacists assisted physicians to formulate preliminary therapeutic plan. Reviewing relevant guidelines， domestic and foreign literatures， clinical pharmacists suggested to combine with dexamethasone so as to relieve inflammatory reaction. According to the results of drug sensitivity test， based on vancomycin plasma concentration monitoring and population pharmacokinetics model fitting， clinical pharmacists suggested to reduce the dose of vancomycin to 0.5 g， ivgtt， q12 h. The pharmaceutical care were conducted throughout the therapy， including efficacy evaluation of anti-infective therapy， ADR monitoring， renal function monitoring， etc. RESULTS： Physicians adopted some suggestions of clinical pharmacists. The disease condition of the patient was recovred， and no ADR related to vancomycin was found. On the 16th day， the patient was discharged from the hospital. CONCLUSIONS： Clinical pharmacists participate in treatment of purulent meningitis， assist physicians to optimize therapy plan based on relevant guideline， literature， etiological examination， blood concentration monitoring and pharmacokinetics model fitting results. It not only guarantee therapeutic efficacy of anti-infective therapy， but also prevent and reduce the occurrence of ADR.