OBJECTIVE： To study the preventive effect of Qingnao tablet on cerebral ischemia-reperfusion injury in rats. METHODS： Rats were randomly divided into sham operation group， model group， Naoluotong capsule group （positive control， 0.05 g/kg）， Qingnao tablet high-dose， medium-dose， low-dose groups （1.52， 0.76， 0.38 g/kg）， 10 in each group. Rats in all administration groups were intragastrically given relevant medicines， rats in sham operation group and model group were intragastrically given equal volume of sodium carboxymethylcellulose solution， once a day， for 5 d. After 1 h of last administration， all rats were induced for cerebral ischemia-reperfusion injury model by suture-occluded method except for sham operation group. After 22 h of ischemia-reperfusion， neurological function deficit scoring was conducted； the pathological changes of the hippocampus were observed； superoxide dismutase （SOD）， adenosine triphosphate （ATP）， lactate dehydrogenase （LDH）， tumor necrosis factor α （TNF-α） levels in brain tissue were measured. RESULTS： Compared with sham operation group， rats in model group appeared different degrees of neurological deficits （score declined）， sparse neurons， irregularly arranged in hippocampus as well as other pathological changes； ATP， SOD levels in brain tissue were decreased （P＜0.01）， LDH， TNF-α levels were increased （P＜0.01）. Compared with model group， neurological function deficit scores in Qingnao tablet doses groups were increased （P＜0.05）， neurological deficits were improved. Except for sham operation group， brain tissue indexes in other administration groups were significantly improved （P＜0.05 or P＜0.01）. CONCLUSIONS： Qingnao tablet can increase ATP and SOD levels in brain tissue homogenate of model rats with cerebral ischemia-reperfusion， decrease LDH and TNF-α levels， and obviously improve rats’ cerebral ischemia-reperfusion injury.