OBJECTIVE： To investigate the effects of rosuvastatin combined with berberine hydrochloride on related indexes in patients with acute cerebral infarction. METHODS： Medical information of 120 patients diagnosed as acute ischemic cerebral infarction were analyzed retrospectively， and they divided into observation group （65 cases） and control group （55 cases） according to route of administration. Both groups were given routine treatment； control group was additionally given Rosuvastatin calcium tablets 10 mg orally before bedtime， once a day； observation group was additionally given Berberine hydrochloride tablets 0.3 g orally， 3 times a day， on the basis of control group. Treatment courses of 2 groups lasted for 14 d. The levels of TC， TG， LDL-C，HDL-C， hs-CRP， ox-LDL， NIHSS score， ADL score， TPA， IMT， Crouse score， the number of unstable plaque and ADR were observed and compared between 2 groups before and after treatment. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， the serum levels of TC， TG， LDL-C， hs-CRP and ox-LDL in 2 groups were significantly lower than before， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. After treatment， NIHSS score of 2 groups were significantly lower than before， and ADL score， HDL-C levels were significantly higher than before， with statistical significance （P＜0.05）； there was no statistical significance between 2 groups （P＞0.05）. After treatment， there was no statistical significance in IMT， Crouse score and the number of unstable plaque in control group compared to before treatment （P＞0.05），but in observation group were significantly lower than before treatment， and also lower than control group at corresponding period， with statistical significance （P＜0.05）. There was no statistical significance in TPA between 2 groups before and after treatment（P＞0.05）. There was no statistical significance in the indcidence of ADR between 2 groups during treatment（P＞0.05）. CONCLUSIONS： Based on routine treatment，rosuvastatin combined with berberine hydrochloride could effectively reduce blood lipid levels in patients with acute cerebral infarction， stabilize or reverse atherosclerotic plaque， and reduce inflammation and oxidative stress with good safety.