OBJECTIVE： To study the effect and its possible mechanism of Xuezhiping capsule on blood lipid levels of high blood lipid model golden hamsters. METHODS： Golden hamsters were randomly divided into normal control group， model group， atorvastatin group （3 mg/kg）， combination group （Xuezhiping capsule 1.3 g/kg+atorvastatin 1.5 mg/kg）， Xuezhiping capsule low-dose， medium-dose， high-dose groups （Xuezhiping capsule 1.3， 2.6， 5.2 g/kg）， 10 in each group. Hamsters in normal control group received normal diet， the other groups were given high-fat diet to establish high blood lipid model. Then relevant drugs were intragastrically given 2 weeks later. Normal control group and model group were intragastrically given equal volume of distilled water， once a day， for 4 weeks. After last administration， blood lipid indexes （TG， TC， HDL-C， LDL-C， FFA）， mRNA and protein expressions of lipid metabolism related genes （PPAR-α， CYP7A1， ACOX， SREBP-1c， ACC1） were detected. RESULTS： Compared with normal control group， serum contents of TC， TG， LDL-C， FFA in model group increased， HDL-C content decreased； PPAR-α， CYP7A1， ACOX mRNA and protein expressions were weakened， SREBP-1c， ACC1 mRNA and protein expressions were enhanced （P＜0.05）. Compared with model group， above-mentioned indexes were obviously improved in Xuezhiping capsule high-dose group， atorvastatin group and combination group （except for HDL-C in Xuezhiping capsule high-dose group） （P＜0.05）； TC， TG， FFA contents， and PPAR-α， CYP7A1， ACOX， ACC1 mRNA， and CYP7A1， SREBP-1c， ACC1 protein were obviously improved in Xuezhiping capsule medium-dose group （P＜0.05）； TC， TG contents， and PPAR-α mRNA， and CYP7A1， SREBP-1c protein were obviously improved in Xuezhiping capsule low-dose group （P＜0.05）. CONCLUSIONS： Xuezhiping capsule has a promising effect of lowering blood lipid， the mechanism may be related to activating PPAR-α and inhibiting SREBP-lc signaling pathway.