OBJECTIVE： To investigate the effects of Xuebijing injection on inflammatory factors， oxidation stress level and thrombosis risk in patients with acute non-ST elevation myocardial infarction （NSTEMI）. METHODS： A total of 130 NSTEMI patients selected from our hospital during May 2015-Aug. 2016 were divided into control group and observation group according to random number table， with 65 cases in each group. Control group was given routine treatment as lowering blood pressure， lowering lipid， anticoagulation and antiplatelet. Observation group was additionally given Xuebijing injection 50 mL， ivgtt， q12 h， on the basis of control group. Both groups were treated for a week. The levels of inflammatory cytokines （TNF-α， IL-6， IL-10， hs-CRP）， SOD， MDA， MMP-9， platelet aggregation rate and fibrinogen were observed in 2 groups before and after treatment. The treatment course， the occurrence of MACE and bleeding event were also recorded. RESULTS： Before treatment， there was no statistical significance in the levels of inflammatory factors， SOD， MDA， MMP-9， platelet aggregation rate or fibrinogen between 2 groups （P＞0.05）. After treatment， the levels of TNF-α， IL-6， hs-CRP， platelet aggregation rate or fibrinogen in 2 groups were decreased significantly， while the level of IL-10 was increased significantly； the improvement of above indexes in observation group was significantly better than control group. The levels of SOD and MMP-9 in 2 groups were increased significantly， while the level of MDA was decreased significantly. The level of SOD in observation group was significantly higher than control group， while the level of MDA was significantly lower than control group， but the level of MMP-9 was significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of MACE （16.92％ vs. 20.00％） or bleeding event （4.62％ vs. 7.69％） between 2 groups （P＞0.05）. CONCLUSIONS： Xuebijing injection shows significant therapeutic efficacy for NSTEMI， effectively inhibits inflammation， and oxidative stress and reduces the risk of thrombosis with good safety.