OBJECTIVE： To provide reference for standardizing the clinical use of carbapenem antibiotics and controlling drug-resistant bacteria infection. METHODS： The detection of 3 kinds of carbapenems-resistant Gram-negative bacillus in our hospital during 2011-2016 were analyzed retrospectively. The consumption， target cure rate and treatment course of carbapenem antibiotics were analyzed statistically. The correlation between detection rate of drug-resistant bacteria with the consumption of carbapenem antibiotics was investigated by Pearson test. RESULTS： During 2011-2016， 1 222 strains of carbapenems-resistant Acinetobacter bauman （CRAB）， 655 strains of carbapenems-resistant Pseudomonas aeruginosa （CRPA） and 53 strains of carbapenem-resistant Escherichia coli （CRE） were detected in our hospital. The detection rates increased from 23.88％， 8.92％， 0.09％ in 2011 to 80.34％， 35.74％， 0.97％ in 2016. The types of carbapenem antibiotics in our hospital were mainly imipenem and meropenem. The consumption of them increased from 4 222， 145 g in 2011 to 7 218， 4 387 g in 2016. The both target cure rates were all lower than 60％， and the proportion of the patients with treatment course ＞14 d was more than 65％. The detection rates of CRAB， CRPA and CRE were positively correlated with the consumption of carbapenem antibiotics （r＞0.9，P＜0.05）. CONCLUSIONS： The detection rate of carbapenems-resistant Gram-negative bacillus and drug consumption increase year by year in our hospital， and they have certain correlation. The target cure rate of carbapenem antibiotics in our hospital is in low level， and there is a long treatment course. They are should be standardized in the clinic. The selection of carbapenem antibiotics should be strictly followed clinical indications so as to reduce the generation of drug-resistant strains.