OBJECTIVE： To compare the effects of different doses of ramipril on blood pressure and renal function of early diabetic nephropathy patients. METHODS： A total of 108 patients with early diabetic nephropathy selected from our hospital during May 2014-Dec. 2015 as research objects were divided into group A， B， C， with 36 cases in each group. All groups were given Ramipril tablets， 5 mg for group A， 2.5 mg for group B， 1.25 mg for group C， qd， for 8 weeks. Blood pressure （SBP， DBP） and renal function indexes （24 h urine protein， β2-microglobulin， UAE） were compared among 3 groups before and after treatment. The occurrence of ADR was also recorded in 3 groups. RESULTS： Before treatment， there was no statistical significance in blood pressure or renal function indexes among 3 groups （P＞0.05）. After treatment， blood pressures 24 h urine protein， β2-microglobulin and UAE of 3 groups were decreased significantly； those indexes of group A were significantly lower than group B and C， with statistical significance （P＜0.05）. There was no statistical significance in each index between group B and C （P＞0.05）. Both hypotension and hypoglycemia occurred in 3 groups during treatment， but were recovered after stopping treatment. CONCLUSIONS： High dose of ramipril （5 mg，qd） shows good effects on early diabetic nephropathy and reduces urinary protein excretion， but doesn’t affect its safety.