OBJECTIVE： To explore the effects of ursodeoxycholic acid and adenosine methionine combined with polyene phosphatidylcholine on related indicators of pregnancy with intrahepatic cholestasis （ICP）. METHODS： Medical information of 90 ICP female were analyzed retrospectively and divided into control group （45 cases） and observation group （45 cases） according to drug use. Control group was given Ursodeoxycholic acid tablet 300 mg orally， 3 times a day+Transmetil for injection 1 g added into 5％ Glucose injection 250 mL intravenously， once a day. Observation group was additionally given Polyene phosphatidylcholine injection 15 mL added into 5％ Glucose injection 250 mL intravenously， once a day， on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. The itching score， the levels of serum total bile acid （TBA）， ALT and AST， pregnancy outcome and the occurrence of ADR were observed in 2 groups before and after treatment. RESULTS： Before treatment， there was no statistical significance in itching score， the levels of TBA， ALT and AST between 2 groups （P＞0.05）. After treatment， itching score， the levels of TBA， ALT and AST in 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The cesarean section rate， premature birth rate， fetal distress rate and amniotic fluid rate of observation group were significantly lower than those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Ursodeoxycholic acid， ademetionine combined with polyene phosphatidylcholine can effectively alleviate itching symptoms， liver function and pregnancy outcome of ICP patients， with good safety.