OBJECTIVE： To systematically review the difference of phlebitis induced by Alprostadil injection with different administration routes， and to provide evidence-based reference for clinical rational use. METHODS： Retrieved from PubMed， EMBase， Cochrane Library， CBM， CJFD， VIP and Wanfang database， RCTs about phlebitis induced by Alprostadil injection with different administration routes were collected. Meta-analysis was conducted by Rev Man 5.2 statistical software after literature screening， data extraction and quality evaluation according to Cochrane System Evaluator’s Manual 5.1.0. RESULTS： A total of 20 RCTs were included， involving 2 562 patients. The results of Meta-analysis showed that the incidence of phlebitis induced by intravenous injection was significantly higher than that induced by intravenous dripping [OR＝4.11，95％CI（1.59，10.67），P＝0.004] and intravenous pump [OR＝3.50，95％CI（1.50，8.16），P＝0.004]. The incidence of phlebitis induced by general apparatus infusion was significantly higher than that induced by fine filtering infusion [OR＝0.03，95％CI（0.01，0.08），P＜0.001]， with statistical significance. CONCLUSIONS： The incidence of phlebitis induced by low-concentration of Alprostadil injection or fine filtering infusion is lower， and that of intravenous injection is higher.