OBJECTIVE： To establish a method for simultaneous determination of tanshinol， caffeic acid， rosmarinic， salvianolic acid B， salvianolic acid A， tanshinoneⅠ， cryptotanshinone， tanshinone ⅡA and ursolic acid in Compound xueshuantong capsules. METHODS： UPLC-MS/MS method was adopted. The determination was performed on ACQUITY UPLC® BEH C18 column with mobile phase consisted of acetonitrile-0.1％ formic acid （gradient elution） at the flow rate of 0.2 mL/min. The column temperature was 40 ℃， and the temperature of injector was 10 ℃. Analysis time was 7 min， and sample size was 5 μL. The electrospray ionization source （ESI） was used； ion source temperature was 150 ℃； capillary voltage was 3.5 kV； cone flow was 50 L/h； desolvation temperature was 350 ℃； desolvation gas flow was 650 L/h； nebuliser pressure was 7×105 Pa； ion monitoring and multiple reaction monitoring （MRM） was performed. RESULTS： The linear ranges of tanshinol， caffeic acid， rosmarinic， salvianolic acid B， salvianolic acid A， tanshinoneⅠ， cryptotanshinone， tanshinone ⅡA and ursolic acid were 10.0-100.0 μg/mL （r＝0.999 8）， 0.1-1.0 μg/mL （r＝0.999 8）， 4.0-40.0 μg/mL （r＝0.999 9）， 10.0-100.0 μg/mL （r＝0.999 9）， 15.0-150.0 μg/mL （r＝0.999 7）， 8.0-80.0 μg/mL（r＝0.999 8）， 10.0-100.0 μg/mL （r＝0.999 7）， 50.0-500.0 μg/mL （r＝0.999 7） and 6.0-60.0 μg/mL （r＝0.999 8）， respectively. The limits of quantitation were 40.0， 9.6， 38.0， 88.0， 130.0， 39.0， 4.4， 3.2 and 10.0 ng/mL， separately. The limits of detection were 12.0， 3.0， 11.0， 26.0， 39.0， 12.0， 1.3， 1.0 and 3.0 ng/mL， respectively. RSDs of precision， stability and reproducibility tests were all lower than 3％. The recoveries were 97.34％-103.20％ （RSD＝2.19％，n＝6）， 97.22％-102.39％ （RSD＝2.03％，n＝6）， 98.51％-101.70％ （RSD＝1.32％，n＝6）， 97.86％-102.49％ （RSD＝2.09％，n＝6）， 96.75％-103.12％ （RSD＝2.36％，n＝6），98.43％-101.65％（RSD＝1.25％，n＝6）， 97.59％-101.50％（RSD＝1.50％，n＝6）， 96.45％-102.88％ （RSD＝2.58％，n＝6）， 97.02％-103.11％ （RSD＝2.38％，n＝6）， separately. CONCLUSIONS： The method is simple and accurate， and can be used for simultaneous determination of 9 components in Compound xueshuantong capsules.