OBJECTIVE： To establish drug use evaluation （DUE） criteria for tigecycline， and to provide reference for rational use of tigecycline. METHODS： Based on tigecycline instructions， referring to related specifications and literatures， DUE criteria for tigecycline was established. And on a basis of it， referring to DUE criteria， in retrospective study， the utilization of tigecycline in 179 inpatients of some one hospital during Nov. 2012-Oct. 2016 was evaluated and analyzed in respects of management indexes， medication indication， medication duration， medication results， etc. RESULTS： The results for DUE of tigecycline in this hospital was that the proportion of patients with consultation records was 83.2％ （aiming at 100％）； microbial inspection rate was 90.5％ （aiming at 80％）； the coincidence rate of medication indication was 98.9％ （aiming at 90％）； the rates of solvent selection， administration route， drug interaction， incompatibility， drug use in special populations meeting the criteria were all 100％ （aiming at 100％）； the rate of prescribing authority was 20.1％ （aiming at 100％）； the rate of drug dosage and medication interval meeting the criteria were 7.3％ （aiming at 100％）； response rate was 54.7％ （aiming at 80％）. CONCLUSIONS： Established DUE criteria of tigecycline can standardize the clinical utilization of tigecycline.