OBJECTIVE： To systematically review therapeutic efficacy of albendazole in the treatment of cystic echinococcosis， and to provide evidence-based reference for clinic treatment. METHODS： Retrieved from PubMed， EMBase， Cochrane library， CBM， CJFD， VIP and Wanfang database， randomized controlled trails（RCTs） about albendazole alone or combined with other positive drugs/surgery in the treatment of cystic echinococcosis were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation according to Cochrane bias risk evaluation tool 5.1.0. RESULTS： A total of 11 RCTs were enrolled， involving 1 020 patients. Results of Meta-analysis showed the response rate of albendazole alone was significantly higher than that of placebo in the treatment of cystic echinococcosis [RR＝4.08，95％CI（1.82，9.14），P＜0.001]； response rate of albendazole+other positive drugs was significantly higher than that of positive drug alone in the treatment of cystic echinococcosis [RR＝1.28，95％CI（1.01，1.63），P＝0.04]； response rate of albendazole+surgery was significantly higher that that of surgery alone in the [RR＝1.22，95％CI（1.10，1.35），P＜0.001]； there was statistical significance. CONCLUSIONS： Both albendazole alone or combined with other positive drugs/surgery show good therapeutic efficacy in the treatment of cystic echinococcosis.