OBJECTIVE： To evaluate the intervention effects of standardized pharmaceutical care on clinical treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） patients. METHODS： A total of 127 AECOPD patients were collected from respiratory medicine department of our hospital during Sept. 2014-Mar. 2015， and then divided into control group （63 cases） and observation group （64 cases） according to random number table. Control group only received traditional medical service and drug therapy. Observation group was additionally given standardized pharmaceutical care provided by clinical pharmacists according to AECOPD clinical pharmacy pathway on the basis of control group. The patients were followed up 1 month after discharge. The use of antibiotics during hospitalization， medication adherence， the occurrence of ADE， patient satisfaction and medication bias during hospitalization and after discharge， the rates of ADR awareness and return visit after discharge were compared between 2 groups. RESULTS： In both groups， 1 patient withdrew from the study during hospitalitation； 33 patients didn’t complete return visit after discharge. During hospitalization， the rate of medication adherence and the total satisfaction of traditional medical procedures and medication guidance in observation group were significantly higher than control group； the utilization ratio of antibiotics and combined use of antibiotics， AUD， the incidence of ADE， the proportion of medication bias were significantly lower than control group， with statistical significance （P＜0.05）. After discharge， the rate of ADR awareness and the total satisfaction of medication guidance in observation group were significantly higher than control group， and the incidence of ADR was significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the rate of medication compliance， the rate of return visit， the proportion of medication bias between 2 groups after discharge （P＞0.05）. CONCLUSIONS： The standardized pharmaceutical care can significantly improve medication compliance and satisfaction of inpatients， contribute to rational use of antibiotics， reduce the incidence of ADE and medication bias， but have no significant effect on medication compliance， the rate of return visit and medication bias of discharged patients.