OBJECTIVE： To improve the process efficiency of automatic dispensation machine before dispensing. METHODS： After building quality control circle （QCC） in the hospital inpatient， according to the steps of QCC， the key links and factors that affect process efficiency of automatic dispensation machine before dispensing were found out， corresponding countermeasures were developed based on causes， then it was evaluated by process time and other indexes in dispensing before and after the development of QCC. RESULTS： The 2 links （removing the drug packaging， manually counting and developing add-drug list） with the longest time before dispensing improved work efficiency by setting add-drug quantity and variety truly， timing checking dispensation medicine， timely counting dispensation medicine drug list， strengthening training and other methods， process time of automatic dispensation machine before dispensing was shortened from 179.8 min （before） to 119.2 min （after） （shortened by 33.7％）， target achievement rate was 168.5％； and QCC staff showed positive growth in means， responsibility， team cohesion， and other aspects （increase rate were 15％-81％）. CONCLUSIONS： QCC shows obvious effect on improving process efficiency of automatic dispensation machine before dispensing.