OBJECTIVE： To evaluate the rationality of cefoxitin use in our hospital. METHODS： Evaluation index and evaluation criteria were established on the basis of DUE. The relative weight of evaluation index were calculated by using attribute-based AHM weight method， and the gas between medical orders and complete rational ones were evaluated by using TOPSIS processing method. The proportion of rational medical orders were calculated to evaluate the rationality of drug use. RESULTS： Among 116 medical records，there were 19％ reasonable medical orders （including 4.3％ complete reasonable medical orders， 5 cases），50％ basically reasonable medical orders（58 cases）and 31％ unreasonable medical orders（36 cases）. CONCLUSIONS： It is reasonable and feasible to use AHM weighted TOPSIS method to evaluate the rationality of cefoxitin. The utilization of cefoxitin in our hospital is basically reasonable， but there are still many problems.