OBJECTIVE： To observe the effects of Gegenqinlian colon positioning tablet （GGQLJC） on colon tissue PPAR-γ， NF-κB p65 protein expressions of model rabbits with damp-heat type ulcerative colitis （UC）. METHODS： 56 rabbits were randomly divided into normal group （normal saline）， model group （normal saline）， sulfasalazine tablet （SASP） group （positive control， 0.300 g/kg）， Gegenqinlian tablet （GGQL） group （0.225 g/kg） and GGQLJC high-dose， medium-dose， low-dose groups （1.036， 0.518， 0.259 g/kg）， 8 in each group. Except for normal group， rabbits in other groups were cultured for damp-heat-type UC model， intragastrically administrated in the second day of last administration， once a day， for 14 d. Disease activity index （DAI）， colonic mucosal damage index （CMDI）， histological damage （TDI） were scored； colon， spleen and thymus indexes were determined； PPAR-γ， NF-κB p65 protein expressions in colon tissue were detected. RESULTS： Compared with normal group， DAI， CMDI， TDI scores and spleen index， colon index， NF-κB p65 protein level in colon tissue in model group were significantly increased （P＜0.01）； thymus index， PPAR-γ protein level in colon tissue were significantly reduced （P＜0.01）. Compared with model group， above-mentioned indexes in each administration group were significantly improved （P＜0.05 or P＜0.01）. Compared with GGQL group， DAI and TDI scores， spleen index， colon index， NF-κB p65 protein level in colon tissue in SASP group， GGQLJC high-dose， medium-dose groups were significantly decreased （P＜0.05）； PPAR-γ protein level in colon tissue in SASP group， GGQLJC high-dose， medium-dose groups were significantly increased （P＜0.05 or P＜0.01）. CONCLUSIONS： GGQLJC has certain improvement effects on model rabbits with damp-heat type UC， which is superior to GGQL. The mechanism may be related to increasing PPAR-γ protein level and decreasing NF-κB p65 protein level in colon tissue.