OBJECTIVE： To observe the clinical effect and safety of Xuebijing injection in the treatment of moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer. METHODS： A total of 130 cases of moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer admitted to our hospital from Jul. 2011 and Jun. 2016 were randomly divided into observation group and control group， with 65 cases in each group. Control group was treated with 0.5％ Iodophor disinfectant to disinfect the sore surface， given wet sterile gauze soaked with 0.5％ Iodophor disinfectant to compress sore surface for 30 min， and then given Aikangfu absorptive silver ion antibacterial healing dressing to fill wound， changed dressing after 2/3 was soaked.  Observation group was additionally given Xuebijing injection 50 mL added into normal saline 100 mL intravenously for 30-40 min， 2-3 times a day， for consecutive 7 days， on the basis of control group. Treatment course of both groups lasted for 4 weeks. The clinical efficacy， the score of pressure ulcer scale for healing （PUSH）， debridement time， the time of local symptom and SIRS disappearance as well as the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （93.85％） was significantly higher than that of control group （80.00％）， and debridement time， the time of local symptom and SIRS disappearance were all significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in PUSH score between 2 groups （P＞0.05）. After 1-4 weeks of treatment， PUSH score of 2 groups was decreased significantly compared to before treatment， and the score of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： For moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer， Xuebijing injection effectively reduces inflammatory exudation， improves the absorption of necrotic tissue， relieves local symptom and systematic inflammatory reaction， promotes the healing of pressure ulcers and has good clinical effect and safety.