OBJECTIVE： To achieve the drug intelligent supervision in transportation within hospital and storage process， and promote quality safety of drugs. METHODS： The function and operation of Radio frequency identification （RFID） medicine logistic box was introduced， its application in one year in inpatient pharmacy of our hospital since Sept. 2013 was summarized， and its application effect and deficiency were analyzed. RESULTS： RFID medicine logistic box showed heat preservation and locking functions， which can be used for the cold-chain medicine and lock packing transportation for the ward. It can achieve information binding after connecting with corresponding platform， record real-time record temperature， logistic box opening and closing information and data， as well as a variety of ways to alarm by SMS and mail， etc. However， failed login server and unpacking caused by unstable wireless signals were found when applying the box， also drug damage and other defects were caused by unreasonable box structure. And the daily average incidence dropped from the initial period （Nov. 2013） 11.9 times （cases） to the late period （Sept. 2014） 3.3 times （cases） after continuous improvement. CONCLUSIONS： Applying of medicine logistic box can strengthen cold-chain transport integrity and regulatory information in our hospital， ensure the safety of drug transport and query traceability of information.