OBJECTIVE： To measure and analysis the related costs of drug-induced liver injury （DILI） from different decision makers， and to provide reference for reducing related costs of DILI， improving medical insurance system and realizing effective health resource distribution. METHODS： In retrospective study， 60 cured or recovered DILI inpatients were randomly selected as subjects from medical record management system of 4 hospitals in Henan province during Jun. 2014-Jun. 2015. Demographic characteristic， clinical characteristic and related cost of DILI were analyzed retrospectively and the cost structure was also analyzed from different decison makers （patient， society， medical insurance payer）. RESULTS： The total direct medical cost of 60 cases was 584 113.05 yuan， and total direct non-medical cost was 31 093.15 yuan and total indirect cost was 169 379.95 yuan. The total cost of DILI offered by patients was 616 296.38 yuan； the total cost of DILI offered by society was 784 586.15 yuan； the total cost of DILI offered by medical insurance was 168 289.77 yuan. CONCLUSIONS： DILI results in serious economic damage for patients and society， deserving attracting extensive attention worldwide. The study provide reference for reducing patient’s medical burden and improving medical insurance system， and contribute to optimize medical resource distribution.