OBJECTIVE： To control the drug quality risk in drug withdrawal links of hospital pharmacy， and provide reference for the application of quality risk management （QRM） in hospital pharmacy. METHODS： Drug QRM was developed in drug withdrawal links through risk identification， risk assessment， risk control， risk assessment and other steps. Using the incidence of risk factors and reusable rate of withdrawal drug as indexes， related data of before （Jul. -Dec. 2015） and after （Jan. -Jun. 2016） developing QRM in our hospital were compared to evaluate the effect of drug QRM. RESULTS： Determining whether specific storage drugs kept the required storage conditions， whether the numbers of withdrawal drugs counted to minimal packaging and other 5 factors were high-risk factors （the risk score of each factor＞4 points）； control measures were taken separately for high risk factors， then high-risk factors were reduced to acceptable levels （risk score＜4 points）. After developing QRM， the incidence of risk factors were reduced than before （reduce 1.35％-6.19％）， reusable rate of withdrawal drug was increased （98.64％ vs. 86.32％） （all P＜0.05）. CONCLUSIONS： Developing QRM in drug withdrawal links of hospital pharmacy can reduce the drug quality risk.