OBJECTIVE： To investigate the effects of lidocaine epidural block combined with general anesthesia on postoperative related indexes of lung cancer patients. METHODS： In retrospective analysis， 108 patients with lung cancer were divided into observation group （56 cases） and control group （52 cases） according to anesthesia method. Both groups were given intravenous dripping of Propofol injection combined with Fentanyl injection， inhaled 1％ sevoflurane for inhalation to assist anesthesia and intermittent intravenous drip of Vecuronium for injection to maintain muscle relaxation. On this basis， observation group was treated with epidural infusion of 2.0％ Lidocaine hydrochloride injection 5 mL/h to maintain anesthesia； control group was given epidural infusion of 0.9％ Sodium chloride injection 5 mL/h to maintain anesthesia. The anesthesia time， operation time， intraoperative bleeding volume， postoperative recovery time， the amount of fentanyl， propofol， vecuronium bromide and sevoflurane， the occurrence of postoperative anesthesia complications （nausea， vomiting， dizziness， drowsiness， skin itching） and other complications （cardiac function insufficiency， cardiovascular events， atrial fibrillation， infection， transient cerebral ischemia， acute coronary comprehensive syndrome， cerebral apoplexy） were observed in 2 groups as well as active and calm VAS score 4 h and 1， 2， 3， 4， 5 after surgery. RESULTS： The anesthesia time， operation time， intraoperative bleeding volume， postoperative recovery time， the amount of fentanyl， propofol， vecuronium bromide and sevoflurane， calm VAS score 4 h， 1 d， 2 d after surgery and active VAS score 4 h， 1 d， 2 d， 3 d after surgery， the incidence of  drowsiness in observation group were significantly shorter or lower than control group， while the incidence of dizziness was significantly higher than control group， with statistical significance （P＜0.05）. There was no statistical significance in the amount of vecuronium， calm and active VAS score in other time， the incidence of nausea， vomiting， skin itching， cardiac function insufficiency， cardiovascular events， atrial fibrillation， infection， transient cerebral ischemia， acute coronary syndrome and stroke between 2 groups（P＞0.05）. CONCLUSIONS： Lidocaine epidural block combined with general anesthesia can reduce the perioperation bleeding amount， postoperative pain， shorten postoperative recovery time and do not increase postoperative complications.