OBJECTIVE： To investigate the effects of Melilotus extract tablet on postoperative therapeutic efficacy of chronic sinusitis endoscopic surgery and the recovery of nasal mucosa. METHODS： The clinical data of 100 patients undergoing chronic sinusitis functional endoscopic surgery in our hospital from May 2015 to Oct. 2016 were analyzed retrospectively and they were divided into control group and observation group according to postoperative treatment， with 50 cases in each group. Two groups received anti-inflammatory， anti-histamine and hemostasis therapy. The control group received Eucalyptol， linonene and pinene enteric soft capsules 0.3 g， tid； observation group was additionally given Melilotus extract tablet 1.2 g， tid， for 6 weeks， on the basis of control group. VAS and Lund-Kennedy endoscopic score were compared between 2 groups before and after treatment. Clinical efficacies and the occurrence of ADR were also compared between 2 groups. RESULTS： there was no statistical significance in VAS score and its total score， Lund-Kennedy endoscopic score and its total score between 2 groups before treatment （P＞0.05）. After treatment， VAS score and its total score， Lund-Kennedy endoscopic score and its total score of 2 groups were significantly decreased， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The cure rate of observation group was 72.0％， which was significantly higher than 44.0％ of control group， with statistical significance （P＜0.05）. There was no significant difference in the incidence of adverse reactions between the 2 groups （P＞0.05）. CONCLUSIONS： Melilotus extract tablet helps to improve clinical efficacy and the recovery of nasal mucosa in patients with chronic sinusitis after endoscopic surgery， with good safety.