OBJECTIVE： To investigate the influence and safety of etomidate or sevoflurane combined with sacral or epidural block anesthesia on anesthesia effects and inflammatory factors. METHODS： 160 children undergoing surgery selected from our hospital during Feb. 2012 to Dec. 2015 were divided into group A and B according to random number table， with 80 cases in each group. Group A was given etomidate 3 mg/（kg·h）for anesthesia maintenance+sacral or epidural block； group B received sevoflurane inhalation 1％-3％ for anesthesia maintenance+sacral or epidural block. The anesthesia effects were compared between 2 groups as well as the levels of serum S100β， NSE， Aβ and inflammatory factors before and after surgery. The occurrence of ADR was observed. RESULTS： There was no statistical significance in SpO2 between 2 groups before and after surgery （P＞0.05）. The anesthesia induction time， postoperative recovery time and heart rate of group A were significantly longer or higher than those of group B， with statistical significance （P＜0.05）. There was no statistical significance in the levels of serum S100β， NSE， Aβ and inflammatory factors between 2 groups before surgery （P＞0.05）. After surgery， the levels of serum S100β， NSE， Aβ， CRP， IL-2 and IL-6 were significantly increased in 2 groups， and group A was significantly higher than group B， with statistical significance （P＜0.05）； there was no statistical significance in TNF-α before and after surgery or between 2 groups （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Sevoflurane combined with sacral or epidural block anesthesia is better than etomidate combin ation anesthesia， with in mild inflammatory reaction and good safety.