OBJECTIVE： To establish a rapid determination method for 9 kinds of glucocorticoid and 8 kinds of non-steroidal anti-inflammatory drugs illegally added into anti-rheumatic TCM patches. METHODS： UPLC-MS/MS method was adopted. The samples were separated on Acquity UPLC® BEN C18 column with methanol-water （90 ∶ 10，V/V） as mobile phase at flow rate 0.4 mL/min. The column temperature was set at 30 ℃， and sample size was 1 μL. The ionization mode was electrospray ion source （ESI）： spray needle voltage of 5 500 V， ion source spray GS1， GS2 pressure of 50， 50 psi， ion source temperature of 500 ℃， scanning range of m/z 50-500. The multiple reaction monitoring（MRM）combined with information-dependent acquisition （IDA） and enhanced product ion scanning （EPI） was used to rapid qualitative analysis. RESULTS： The detection limits for 17 kinds of chemical components were not more than 0.400 μg/mL. RSDs for precision， repeatability， stability tests were not more than 4.93％，7.69％，9.57％， respectively. Diclofenac sodium was detected in the sample. CONCLUSIONS： The method is selective and sensitive. It is suitable for qualitative analysis of chemicals illegally added into anti-rheumatism TCM patches.