OBJECTIVE： To investigate the effects of trastuzumab combined with neoadjuvant chemotherapy on clinical efficacy of breast cancer patients， serum angiogenic factors and apoptosis factors of breast tissue. METHODS： A total of 116 breast cancer in patients were selected from our hospital during Jan. 2012-Dec. 2014 as research object， and then divided into control group and observation group according to random number table， with 58 cases in each group. Control group was given Carboplatin for injection 100 mg（added into 500 mL 5％ Glucose injection after diluted into 10 mg/mL）， ivgtt， 200-400 mg/m2 on the first day of each chemotherapy cycle； Docetaxel injection ivgtt，75 mg/m2 on the first day of each chemotherapy cycle. On the basis of control group， observation group was additionally given Trastuzumab for injection， 4 mg/kg in the first week， 2 mg/kg in the 2nd-8th week， once a week， ivgtt. A treatment course lasted for 3 weeks， and both groups received 6 courses of treatment. Both groups received modified radical mastectomy 2 weeks after treatment. The levels of serum angiogenic factors and apoptosis factors of breast tissue were observed in 2 groups before and after treatment. Clinical efficacies and the occurrence of ADR were compared between 2 groups 1 year after treatment. RESULTS： Before treatment， there was no statistical significance in the levels of serum angiogenic factors and apoptosis factors of breast tissue between 2 groups （P＞0.05）. After treatment， the levels of serum angiogenic factors and apoptosis factors of breast tissue were decreased significantly in 2 groups， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. Clinical response rate of observation group was 82.76％， which was significantly higher than 56.90％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Trastuzumab combined with neoadjuvant chemotherapy is helpful to improve the therapeutic effect with breast cancer

prevent recnrence， and reduce the expression of serum angiogenic factors and apoptosis factors of breast tissue with good safety.